Studies have long suggested that oxytocin — a hormone that can also act as a neurotransmitter — regulates prosocial behavior such as empathy, trust and bonding, which led to its popular labeling as the “love hormone.” Mysteriously, oxytocin has also been shown to play a role in antisocial behaviors and emotions, including reduced cooperation, envy and anxiety. How oxytocin could exert such opposite roles had largely remained a mystery, but a new UC Davis study sheds light on how this may work.
… Read More
Working with California mice, UC Davis researches showed that the “love hormone” oxytocin can sometimes have antisocial effects depending on where in the brain it is made. (Mark Chappell/UC Riverside)
While most oxytocin is produced in an area of the brain known as the hypothalamus, some oxytocin is produced in another brain area known as the bed nucleus of the stria terminalis, or BNST. The BNST is known
Scientists at Cincinnati Children’s used human intestinal organoids grown from stem cells to discover how our bodies control the absorption of nutrients from the food we eat. They further found that one hormone might be able to reverse a congenital disorder in babies who cannot adequately absorb nutrients and need intravenous feeding to survive.
… Read More
Heather A. McCauley, PhD, a research associate at Cincinnati Children’s Hospital Medical Center, found that the hormone peptide YY, also called PYY, can reverse congenital malabsorption in mice. With a single PYY injection per day, 80% of the mice survived. Normally, only 20% to 30% survive.
This indicates PYY might be a possible therapeutic for people with severe malabsorption.
Poor absorption of macronutrients is a global health concern, underlying ailments such as malnutrition, intestinal infections and short-gut syndrome. So, identification of factors regulating nutrient absorption has significant therapeutic potential, the researchers noted.
McCauley was lead author
Scientists at the Center for Infection and Immunity (CII) at Columbia University Mailman School of Public Health have discovered bacteria linked to post-infectious hydrocephalus (PIH), the most common cause of pediatric hydrocephalus worldwide. Results of the study led by Pennsylvania State University with CII scientists and clinical colleagues in Uganda are published in the journal Science Translational Medicine.
… Read More
Hydrocephalus is the most common indication for neurosurgery in children. Of the estimated 400,000 new cases each year, about half are estimated to be post-infectious, with the largest number of cases in low- and middle-income countries, especially sub-Saharan Africa. Neonatal sepsis often precedes PIH, although the manifestations of hydrocephalus typically emerge in the months following the neonatal period as cerebrospinal fluid accumulates so that cranial expansion garners medical attention. These infants typically die in early childhood without advanced surgical management.
Study co-first author Brent L. Williams, PhD, assistant professor of epidemiology