N-acetylglucosamine, a simple sugar found in human breast milk and sold as an over-the-counter dietary supplement in the United States, promotes myelin repair in mouse models and correlates with myelination levels in multiple sclerosis patients according to a new University of California, Irvine-led study.
Published in the Journal of Biological Chemistry, the study also demonstrates that in mice, delivering N-acetylglucosamine orally to lactating mothers drove primary myelination in their nursing offspring. N-acetylglucosamine is a simple sugar that is metabolically attached to proteins at the cell surface to control cellular function.
“We found that N-acetylglucosamine activates myelin stem cells to promote primary myelination and myelin repair,” said Michael Demetriou, MD, PhD, FRCP(C), professor of neurology, microbiology and molecular genetics at UCI School of Medicine and leader of the study. “Our data raises the intriguing possibility that N-acetylglucosamine may be a simple therapy to promote myelin repair in multiple sclerosis patients.”
A team of researchers in the United States and Japan reports that spinal cord stimulation (SCS) measurably decreased pain and reduced motor symptoms of Parkinson’s disease, both as a singular therapy and as a “salvage therapy” after deep brain stimulation (DBS) therapies were ineffective.
Writing in the September 28, 2020 issue of Bioelectronic Medicine, first author Krishnan Chakravarthy, MD, PhD, assistant professor of anesthesiology at University of California San Diego School of Medicine, and colleagues recruited 15 patients with Parkinson’s disease, a neurodegenerative disorder that is commonly characterized by physical symptoms, such as tremors and progressive difficulty walking and talking, and non-motor symptoms, such as pain and mental or behavioral changes.
The mean age of the patients was 74, with an average disease duration of 17 years. All of the patients were experiencing pain not alleviated by previous treatments. Eight had undergone earlier DBS, a non-invasive, pain therapy in
Agencies from Arizona to Florida reported outages that typically lasted about 30 minutes before being restored.
The 911 problems occurred the same night that widespread outages were reported for Microsoft services.
Redmond, Washington — home of Microsoft’s headquarters — tweeted Monday that city phones and emails were also experiencing outages.
The service health status page for Microsoft Azure — the company’s cloud computing service — posted, “A subset of customers in the Azure Public and Azure Government clouds may encounter errors performing authentication operations for a number of Microsoft or Azure services.” Microsoft said customers “should see signs of recovery.”
A spokesperson for the sheriff’s office in Hennepin County, Minnesota, told CNN they were not sure whether their 911 outage was related to the Microsoft issue.
The New York Police Department told CNN that while their 911 services had no reported outages, they did experience issues with Microsoft accounts.
Researchers say they have discovered a group of lakes hidden under Mars’ icy surface
This follows the detection of another subsurface lake in the same region in 2018
The findings revived the debate on whether the Red Planet has alien life or can house microorganisms
A team of Italian scientists discovered a group of three salty ponds beneath Mars’ south pole. The findings revived the debate on whether the Red Planet has alien life or at least can house microorganisms.
The discovery of these ponds raised the possibility that microbial organisms could survive on Mars but the only hindrance was the high amount of salt concentration, which could be keeping the waters frozen, scientists said in a report published on Sept. 28 in Nature Astronomy.
The discovery of the salty ponds was significant because their locations were close to another lake discovered in 2018. The largest of them
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AB Science Presents Phase 2B/3 Study Results in Progressive Multiple Sclerosis at the World’s Largest Multiple Sclerosis Research Conference
50% of patients suffering from multiple sclerosis have one of the progressive forms of the disease, for which there is no satisfactory treatment to date
Masitinib, a tyrosine kinase inhibitor developed by AB Science, provides the first clinical evidence that targeting the innate immune system is an effective strategy for the treatment of progressive forms of multiple sclerosis.
AB Science SA (Euronext – FR0010557264 – AB), a pharmaceutical company specialized on the research, development and commercialization of protein kinase inhibitors (PKIs), announced today that it has presented the world’s first key results from its Phase 2B/3 study (AB07002) evaluating its lead product, masitinib, in both progressive forms of multiple sclerosis1 during the 8th Joint Meeting of
Microsoft has had to contend with quite a number of major leaks over the last few years, including everything from parts of the Windows 10 source code in 2017 to a Bing app server that recently leaked multiple terabytes of GPS data and user searches for more than week. On top of all that, it appears that a ~43GB archive of Microsoft source code, including the Windows XP (with Service Pack 1) and Windows Server 2003 operating systems, has reportedly leaked, along with a array of older OSes, including a few versions of Windows CE and MS-DOS.
Both Windows XP SP1 and Windows Server 2003 have been EOL for quite some time now. Current estimates put Windows XP’s market share at about 1.26% (and falling). Windows Server 2003’s share among connected servers is even lower and is estimated to be approximately .57% as of today. The
Facebook said Thursday that it had removed accounts from three disinformation campaigns, each with at least loose ties to the Kremlin.
None of the three had a large following or were focused primarily on targeting Americans. But they shared similar tactics, and each came from a distinct Russia-linked agency, indicating the country’s leadership is doubling down on building disinformation networks in the months before the U.S. election.
Facebook, Instagram and Twitter have since suspended the accounts that tried to cultivate followings to point users back to their websites. In each case, the number of accounts and their followers are a fraction of the size of similar campaigns that went viral in the lead-up to the 2016 election, indicating they’re being caught earlier.
While each was still in their infancy and didn’t display a clear intent, one possibility is that they would eventually be used to disseminated hacked information, in the