‘Like a fishing net,’ nanonet collapses to trap drug molecules

'Like a fishing net,' nanonet collapses to trap drug molecules
a Chemical structure of PPSU showing the polymer backbone and oxygen atoms that carry positive/negative (blue/red) atomic partial charges, respectively. b Atomistic simulation snapshot showing a dissolution-complementarity equilibrium in DMSO for six PPSU20 chains. Inset is a superstructure formed by PPSU self- complementarity. c PPSU self-complementarity leading to a 2D reversible superstructure with enrichment of oxygen atoms on the surface. Formation of 3D superstructures is inhibited in DMSO due to the strong repulsion among layers. d Average dipolar energies per dipole-dipole pair of sulfone–sulfone and sulfone-solvent. Error bars represent the standard deviation from three parallel simulations. e Atomistic simulation snapshot showing the formation of a 3D superstructure through PPSU bundling in water. Inset showing the 3D superstructure with or without water molecules. Credit: Nature Communications (2020). DOI: 10.1038/s41467-020-18657-5

Northwestern University researchers are casting a net for nanoparticles.


The team has discovered a new, rapid method for fabricating nanoparticles from a

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