Breakthrough discovery in gene causing severe nerve conditions — ScienceDaily

Researchers have made a breakthrough genetic discovery into the cause of a spectrum of severe neurological conditions.

A research study, led by the Murdoch Children’s Research Institute (MCRI) and gracing the cover of and published in the October edition of Human Mutation, found two new mutations in the KIF1A gene cause rare nerve disorders.

MCRI researcher Dr Simranpreet Kaur said mutations in the KIF1A gene caused ‘traffic jams’ in brain cells, called neurons, triggering a devastating range of progressive brain disorders. KIF1A-Associated Neurological Disorders (KAND) affects about 300 children worldwide.

“KAND symptoms often appear at birth or early childhood, have varying severity and can result in death within five years of life. Because clinical features overlap with other neurological disorders, children can be misdiagnosed or remain undiagnosed for a long period of time,” she said.

“Our study will lead to more diagnoses by expanding the mutation pool further, finding

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Nerve cell activity shows how confident we are — ScienceDaily

Should I or shouldn’t I? The activity of individual nerve cells in the brain tells us how confident we are in our decisions. This is shown by a recent study by researchers at the University of Bonn. The result is unexpected — the researchers were actually on the trail of a completely different evaluation mechanism. The results are published in the journal Current Biology.

You are sitting in a café and want to enjoy a piece of cake with your cappuccino. The Black Forest gateau is just too rich for you and is therefore quickly eliminated. Choosing between the carrot cake and the rhubarb crumble is much trickier: The warm weather favors the refreshingly fruity cake. Carrot cake, however, is one of your all-time favorites. So what to do?

Every day we have to make decisions, and we are much more confident about some of them than others. Researchers

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