Tissues and cells in the human body are subjected to a constant push and pull — strained by other cells, blood pressure and fluid flow, to name a few. The type and direction of the force on a cell alters gene expression by stretching different regions of DNA, researchers at University of Illinois Urbana-Champaign and collaborators in China found in a new study.
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The findings could provide insights into physiology and diseases such as fibrosis, cardiovascular disease and malignant cancer, the researchers said.
“Force is everywhere in the human body, and both external and internal forces can influence your body far more than you may have thought,” said study leader Ning Wang, a professor of mechanical science and engineering at Illinois. “These strains profoundly influence cellular behaviors and physiological functions, which are initiated at the level of gene expression.”
The effects of physical forces and signals on cells, tissues and
Women who have suffered unexplained repeated pregnancy loss (uRPL) have altered perceptions and brain responses to male body odours, in comparison to those with no history of uRPL, suggests a new study published today in eLife.
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The results could lead to urgently needed answers for many women who experience repeat miscarriage with no clear underlying explanation.
Around 50% of human conceptions and 15% of human pregnancies result in miscarriage, but only a limited number of these can be explained. Body odour has been linked to many aspects of healthy human reproduction — such as synchrony of menstruation between women who live together, and the influence of body odours of breast-feeding women on the timing of ovulation and menstruation in others.
“Given that sense of smell is associated with human reproduction, we hypothesised that it may also be related to disorders of human reproduction,” explains lead author Liron Rozenkrantz, who