Quality control mechanism closes the protein production ‘on-ramps’ in cells

Quality control mechanism closes the protein production 'on-ramps'
An illustration of stalled ribosomes as stalled cars on a freeway. New work shows that factors GIGYF2 and 4EHP prevent translation from being initiated on problematic messenger RNA fragments. This is akin to closing an on-ramp to prevent additional traffic backups after an incident. Credit: Kamena Kostova and Navid Marvi.

Recent work led by Carnegie’s Kamena Kostova revealed a new quality control system in the protein production assembly line with possible implications for understanding neurogenerative disease.


The DNA that comprises the chromosomes housed in each cell’s nucleus encodes the recipes for how to make proteins, which are responsible for the majority of the physiological actions that sustain life. Individual recipes are transcribed using messenger RNA, which carries this piece of code to a piece of cellular machinery called the ribosome. The ribosome translates the message into amino acids—the building blocks of proteins.

But sometimes messages get garbled. The resulting incomplete

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Wingman Ventures: Swiss VC fund closes $83 million for startups

  • Swiss VC fund Wingman Ventures has closed an $83 million early-stage fund to invest in Swiss startups.
  • Wingman only invests in pre-seed and seed stage startups out of Switzerland, where it believes there is a significantly underserved tech ecosystem.
  • “Swiss founders have traditionally been funded by risk averse, corporate backers and don’t understand the broader tech ecosystem,” Wingman Ventures partner Alex Stöckl said.
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Swiss VC fund Wingman Ventures has closed a 76CHF million ($83 million) early-stage fund.

Wingman invests in pre-seed and seed stage startups out of Switzerland, where it believes there is a significantly underserved tech ecosystem.

The country of just 8 million people is one of the wealthiest nations in the world, but has a certain insularity which has prevented its growth as a tech ecosystem, according to Wingman Ventures founding partner, Alex Stöckl. 

“Swiss founders have traditionally been funded by

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Wall Street closes up on tech rally despite mixed signs on economic rebound

(Reuters) – Wall Street rallied in a rocky session on Thursday as beaten-down technology shares gained favor after data showing a surge in the sale of new homes revived faith in the economic recovery even as U.S. jobless claims rose unexpectedly.

FILE PHOTO: The Wall Street sign is pictured at the New York Stock exchange (NYSE) in the Manhattan borough of New York City, New York, U.S., March 9, 2020. REUTERS/Carlo Allegri/File Photo

Stocks also reacted positively to news of efforts to enact further stimulus in Washington, helping lift the S&P to a session high, although the index then turned negative before retracing some gains.

Apple Inc AAPL.O, Amazon.com Inc AMZN.O, Nvidia Corp NVDA.O and Facebook Inc .FB.O, stocks that have outperformed at a time of increased economic uncertainty, all rose.

The wild session indicated caution was in store, said Dennis Dick, a trader at Bright Trading

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S&P 500 closes at lowest level since July as tech shares fall anew

Stocks accelerated losses into the close, erasing earlier gains and ending an advance that began on Tuesday. The S&P 500, Dow and Nasdaq each had their worst day in two weeks.

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The S&P 500 sank more than 2%, led by a drop in the energy and information technology sectors, to close at its lowest level since the end of July. The Nasdaq’s more than 3% decline brought the index down also to near a two-month low.

The Dow fell to its lowest close since the beginning of August, even as shares of component stock Nike Nike (NKE) climbed to a record high after reporting quarterly results that far surpassed consensus expectations. However, the increase was offset in the Dow by declines in tech names including Salesforce and Apple.

Shares of Stitch Fix (SFIX) sank more than 15%, after the digital personal styling service posted a wider than expected

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