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The compound thymoquinone (TQ) selectively kills prostate cancer cells at advanced stages, according to a new study published in Oncogene. Led by researchers at Kanazawa University, the study reports that prostate cancer cells with a deletion of the SUCLA2 gene can be therapeutically targeted. SUCLA2-deficient prostate cancers represent a significant fraction of those resistant to hormone therapy or metastatic, and a new therapeutic option for this disease would have immense benefits for patients.
Hormone therapy is often chosen for the treatment of metastatic prostate cancer but nearly half of patients develop resistance to the treatment in as little as 2 years. A mutation in RB1, a tumor suppressor gene that keeps cell growth under control, has been pegged as a particularly strong driver of treatment resistance and predicts poor outcome in patients.
“Mutations in tumor suppressor genes are enough to induce initiation and malignant progression of prostate cancer, but
Stanford University scientists have identified a new class of solid materials that could replace flammable liquid electrolytes in lithium-ion batteries.
The low-cost materials — made of lithium, boron and sulfur — could improve the safety and performance of electric cars, laptops and other battery-powered devices, according to the scientists. Their findings are published in a study in the journal ACS Applied Materials & Interfaces.
“A typical lithium-ion battery has two solid electrodes with a highly flammable liquid electrolyte in between,” said study lead author Austin Sendek, a visiting scholar in Stanford’s Department of Materials Science & Engineering. “Our goal is to design stable, low-cost solid electrolytes that also increase the power and energy output of the battery.”
Battery electrolytes shuttle lithium ions between the positive and negative electrode during charging and discharging. Most lithium-ion batteries use a liquid electrolyte that can combust if the battery is punctured
An international collaboration of scientists from the UK, Norway and the U.S. have identified genetic evidence supporting a causal effect of smoking and obesity on increasing susceptibility to severe COVID-19 and sepsis.
Published online in Circulation today, the results show that both smoking and higher body mass index (BMI, a measure of obesity) increase risk of severe COVID-19. The same was also true for the risk of developing sepsis, which is a dangerous inflammatory response to infection, experienced by many patients with severe COVID-19.
Confirming the causal connection also highlights that stopping smoking and losing weight can be effective interventions for reducing the risk of developing severe COVID-19 and sepsis.
Led by Dr. Dipender Gill, from St George’s, University of London and Imperial College London, the “Mendelian randomisation” study considered separate datasets of 3,199 patients with severe COVID-19 and 10,154 patients with sepsis. Using genetic
Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité — Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered that some SARS-CoV-2 antibodies bind to tissue samples from various organs, which could potentially trigger undesired side effects. They report their findings in the scientific journal Cell.
Initially, the scientists isolated almost 600 different antibodies from the blood of individuals who had overcome COVID-19, the disease triggered by SARS-CoV-2. By means of laboratory tests, they were able to narrow this number down to a few antibodies that were particularly effective at binding to the virus. Next, they produced these antibodies artificially using cell cultures. The identified so-called neutralizing antibodies bind to the virus, as crystallographic analysis reveals, and thus prevent the pathogen from entering cells and reproducing. In addition,
Meteorologists track hurricanes over the oceans, forecasting where and when landfall might occur so residents can prepare for disaster before it strikes. What if they could do the same thing for droughts?
Stanford scientists have now shown that may be possible in some instances — the researchers have identified a new kind of “landfalling drought” that can potentially be predicted before it impacts people and ecosystems on land. They found that these droughts, which form over the ocean and then migrate landward, can cause larger and drier conditions than droughts that occur solely over the land. Of all the droughts affecting land areas worldwide from 1981 to 2018, roughly one in six were landfalling droughts, according to the study published Sept. 21 in Water Resources Research.
“We normally don’t think about droughts over the ocean — it may even sound counterintuitive. But just as over land, there can be times