The making of memory B cells and long-term immune responses

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IMAGE: B cell differentiation in GC
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Credit: Osaka University

Osaka, Japan — The current COVID-19 climate has made vaccines, antibodies, and immune responses topics of everyday conversation. Now, it isn’t just immunologists who want to know how our bodies respond to re-infections months, years, or sometimes decades after an initial immune response. A new study by Tomohiro Kurosaki at Osaka University shows that this ability requires Bach2, a protein that regulates the expression of genes needed to instruct activated B cells under selection to become memory B cells.

Like most biological processes, immune responses are complicated. They involve numerous types of cells and proteins, performing precise step-by-step processes. And of course, we don’t know all of them yet. For example, memory B cells are a type of white blood cell that are created in lymph nodes or spleens during an infection. They stick around for years and allow

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Microsoft and Facebook vet leads nonprofit making software to improve COVID-19 rapid tests

Most of the Audere team, gathered together in pre-COVID times. (Audere Photo)

A Seattle-based nonprofit launched to provide digital health solutions for poorer countries is applying its expertise to help with COVID-19 testing.

Audere is building software for administering rapid result COVID tests that can be integrated into products being developed by U.S. manufacturers that use saliva or nasal swab samples.

“There is a critical need for rapid testing,” said Philip Su, CEO and founder of Audere. People are increasingly realizing that the widespread distribution of a vaccine is still many months away. The availability of accurate, inexpensive tests that provide results in minutes can help control the spread of the virus in the meantime, Su said.

Philip Su, Audere CEO and founder. (Audere Photo)

The tests — known generally as rapid diagnostic tests or RDTs — can have high rates of failure, though the basic concept is simple. Imagine

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The new Ring Always Home Camera is a security disaster in the making

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Image: Ring

I have two Ring doorbells at my house and they are far from perfect. The delay and the poor excuse for a mobile app has caused me to actually miss deliveries, but they do a pretty good job of making sure we see who’s visited and can (most of the time) answer the door before the visitor or delivery person shrugs and walks away. The batteries last a good while and the cloud subscription price isn’t so much that our bottom line really feels it.

Other than the network delay between the Ring doorbell, the mobile app, and the Ring Chime, my biggest complaint is the speed at which Ring deploys updates. In fact, the Ring app doesn’t even tell you which version of the firmware it uses. Instead, it just says Up To Date. 

You’d think a company focused on security would make it more apparent. Given

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PlayStation Inventor Starts New Career Making Robots for No Pay

(Bloomberg) — Ken Kutaragi, the legendary inventor of the PlayStation gaming console, is taking on one of the hardest jobs in robotics. And he’s getting paid nothing to do it.

The founder of Sony Corp.’s gaming business is the new chief executive officer of Ascent Robotics Inc., a Tokyo-based artificial intelligence startup. Kutaragi, 70, wants to make affordable robots that can safely move around and do physical work alongside humans in factories and logistics centers, and aims to have a working prototype in about a year. He said he receives no salary to save precious capital.



Ken Kutaragi standing in a room: PlayStation Inventor Ken Kutaragi Starts New Career Making Robots


© Bloomberg
PlayStation Inventor Ken Kutaragi Starts New Career Making Robots

Ken Kutaragi in Tokyo on Oct. 8.

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Photographer: Kentaro Takahashi/Bloomberg

“The Covid-19 outbreak has turned the old argument about robots taking our jobs on its head,” Kutaragi said in his first interview since taking the helm in August. “It’s pretty clear

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Qualcomm to reportedly partner with Asus for making its own gaming smartphone



a hand holding a cellphone: Asus ROG Phone 3 Review (31)


© Provided by BGR.in
Asus ROG Phone 3 Review (31)

Qualcomm recently sent out invites for its upcoming event that is to take place this December. The brand is set to unveil its newest Snapdragon series processors at the event, the highlight of which will be the flagship Qualcomm Snapdragon 875, based on 5nm architecture. Now, as per a new report by DigiTimes, via GSMarena, Qualcomm is also likely to announce its first-ever dedicated gaming smartphone around the same time.

While we don’t have a lot of details, to begin with, the new gaming phone will reportedly be co-developed by Asus. Qualcomm already designs its own boards to flaunt the skills of the latest chipsets. However, making a completely new phone is a whole different ball game, which is why the partnership with Asus makes sense. The new phone may even get the branding of the Asus ROG (Republic

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Information technology will play critical role in making Pakistan self-reliant: PM Imran Khan

Prime Minister Imran Khan addressing the final session of the National Seminar on “Resetting & Rebooting Pakistan’s ICT Sector” at the National Defence University (NDU) in Islamabad, on October 7, 2020. — PID

ISLAMABAD: Prime Minister Imran Khan on Wednesday said the Information and Communication Technology (ICT) sector held great potential for employment generation and revenue and will be critical to Pakistan’s success in the future.

“This government’s goal is a self-reliant Pakistan that can emerge as a global power,” he said.

The prime minister expressed these views while chairing the final session of National Seminar on “Resetting & Rebooting Pakistan’s ICT Sector” at the National Defence University (NDU), a press release issued by the PM Media Office said.

“We need to focus on our youth’s skill development,” said the prime minister.

Chief of Army Staff General Qamar Javed Bajwa, Minister for Science and Technology Fawad Hussain Chaudhry, Governor Sindh

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How This Celebrity Realtor Is Making Diversity And Inclusion His Top Listing

As the drive increases for society to become more inclusive, and provide sustainable and equitable support for Black communities, the real estate sector has come into the spotlight for lack of racial representation.

To date, Rod Watson, founder of The Watson Group LAVIPagent team, and Director of Sports and Entertainment at Keller Williams Beverly Hills, has sold and negotiated over $120 million in real estate during his 14 year career. He says, “I’ve learned a lot of valuable information when it comes to real estate investing. My focus has been to help as many athletes and people of color as I can to generate, and maintain generational wealth through real estate investing. That is my purpose and reason for being in this business.” 

His journey began with a dream to get

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Making Your Own Luck In Your Career

Napoleon famously remarked that he would rather his generals be lucky than good, and it’s something that a recent study from the University of Catania explored, with the researchers attempting to understand the role luck played in our success. They did this by modeling human talent, and specifically how that talent is used by us through our lives. This allowed them to understand the role chance played in our outcomes.

They ran a number of simulations to explore the distribution of wealth and talent and found that it generally wasn’t the most talented that came to be wealthiest, but rather those who were regarded as the luckiest. The model worked by assigning people a given level of talent, which consisted of things such as intelligence and skill. This talent would be randomly assigned throughout the population according to a broad bell curve distribution.

The model then tracked each person

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Is COVID Stress Making You Numb? Stop Blaming Yourself!

After months of combating Covid stress, you might wonder why one more thing – the election, wildfires, civil unrest or boredom setting in – causes you to go numb. You have no feelings and all the common excesses like streaming videos, eating sweets, or pouring an extra glass of wine seem so appealing.

A new approach to dealing with the toxic emotions caused by the pandemic and unrest of 2020 is to see the problem as a stress wire. A wire triggered that numbness! What’s so appealing about this approach, which is emotional brain training, is that we can visualize, target, and switch off the root cause of that numbness in our brain: the stress-reactive neural circuit. 

Laurel Mellin, PhD

Switch off the reactive wire and feel better faster.

Source: Laurel Mellin, PhD

That wire is a “real entity,” a neural circuit. How refreshing. We can use scientific strategies to deal with that

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NASA making 2nd attempt to launch $23 million female-friendly toilet to International Space Station

Northrop Grumman readied for a second launch try Friday evening to send four tons of supplies and equipment to the International Space Station, including a female-friendly $23 million space toilet. The first attempt to launch the Cygnus space station cargo ship atop an Antares rocket Thursday evening was aborted minutes before liftoff.

“When the astronauts have to go, we want to allow them to boldly go,” quipped Jim Fuller of Collins Aerospace, builder of the compact potty.

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A new space toilet undergoing acoustic tests before launch to the International Space Station. The toilet is smaller than the station’s current potty and features improvements to make it more “female friendly.”

NASA


Also on board: a high-resolution virtual reality camera that will be used to document an upcoming spacewalk and 10 bottles of Estée Lauder skin cream that will be part of a zero-gravity commercial photo shoot.

Liftoff from pad 01 at

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