Nuclear magnetic resonance insights set stage for next-gen targeted cancer therapies for adults and children

Nuclear magnetic resonance insights set stage for next-gen targeted cancer therapies for adults and children
First author Tao Xie, Ph.D., and corresponding author Charalampos Babis Kalodimos, Ph.D., chair, both of the Department of Structural Biology at St. Jude, have visualized previously unknown structures of the ABL kinase through the use of an NMR spectrometer. Credit: St. Jude Children’s Research Hospital

Scientists at St. Jude Children’s Research Hospital have visualized previously unknown structures of the ABL kinase, offering insight for designing the next generation of targeted therapies for adult and childhood cancers. The work will advance understanding of treatment resistance to targeted cancer therapies. The findings appear as an advance online publication today in Science.

Central to this achievement was the United States’ most powerful nuclear magnetic resonance (NMR) spectrometer, which was installed at St. Jude in 2019. Just as microscopes enable scientists to peer inside a cell, NMR spectroscopy lets researchers visualize previously invisible, or undetectable, molecular structures that cannot be seen with other

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Seattle startup Resonance AI raises $2.2M to analyze dialogue, mood, music in video content

The Resonance.AI team, including co-founder Tom Chiarella (far right, second row), and co-founder Randa Minkarah (second from left, second row).

TV news broadcasters, productions studios, and others are using technology from a Seattle startup to analyze their video content and make changes based on audience reception.

Resonance AI recently reeled in $2.28 million of a larger investment round to fuel growth of its video analysis platform that uses artificial intelligence to measure dialogue, music, mood, lighting, pacing, movement, and more.

The startup provides data that helps content creators figure out what resonates with an audience. It can answer questions such as: Who is my most valuable talent? What types of stories resonate by market? Is the editing of my show too fast-paced?

The 6-year-old startup is led by CEO and co-founder Tom Chiarella, a former exec at Statera and General Electric, as well as president and co-founder Randa Minkarah, a

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