Scientists at St. Jude Children’s Research Hospital have visualized previously unknown structures of the ABL kinase, offering insight for designing the next generation of targeted therapies for adult and childhood cancers. The work will advance understanding of treatment resistance to targeted cancer therapies. The findings appear as an advance online publication today in Science.
Central to this achievement was the United States’ most powerful nuclear magnetic resonance (NMR) spectrometer, which was installed at St. Jude in 2019. Just as microscopes enable scientists to peer inside a cell, NMR spectroscopy lets researchers visualize previously invisible, or undetectable, molecular structures that cannot be seen with other