Low cost and ease of manufacturing allow for wide application in developing countries — ScienceDaily

Electrical engineers, computer scientists and biomedical engineers at the University of California, Irvine have created a new lab-on-a-chip that can help study tumor heterogeneity to reduce resistance to cancer therapies.

In a paper published today in Advanced Biosystems, the researchers describe how they combined artificial intelligence, microfluidics and nanoparticle inkjet printing in a device that enables the examination and differentiation of cancers and healthy tissues at the single-cell level.

“Cancer cell and tumor heterogeneity can lead to increased therapeutic resistance and inconsistent outcomes for different patients,” said lead author Kushal Joshi, a former UCI graduate student in biomedical engineering. The team’s novel biochip addresses this problem by allowing precise characterization of a variety of cancer cells from a sample.

“Single-cell analysis is essential to identify and classify cancer types and study cellular heterogeneity. It’s necessary to understand tumor initiation, progression and metastasis in order to design better cancer treatment

Read More

The fisheye lens goes flat and wide

Fisheye lenses let photographers take panoramic views in a single shot but, because they are made from multiple pieces of curved glass, they tend to be bulky and expensive.

Engineers in the US may have taken an important step in addressing this by creating what they say is the first flat fisheye lens capable of producing clear 180-degree images.

It’s a type of metalens: a wafer-thin material patterned with microscopic features that work together to manipulate light in a specific way.

And while it currently only works in the infrared part of the spectrum, the researchers say it could be modified to capture images using visible light.

The work by a team from Massachusetts Institute of Technology (MIT) and the University of Massachusetts at Lowell is described in a paper in the journal Nano Letters.

“This design comes as somewhat of a surprise, because some have thought it would

Read More